CAS No.: 475-83-2
荷叶碱 Catalog No. CSN11590
Synonyms: Sanjoinine E;(-)-Nuciferine;VLT 049|
Nuciferine is naturally occuring alkaloid found in the plants Nymphaea caerulea and Nelumbo nucifera as a potent inverse agonist at human 5-HT7 receptor.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 5-HT Receptor 2C
IC50:131nM5-HT Receptor 7
IC50:150nM5-HT Receptor 2B
IC50:1μMDopamine Receptor D5
EC50:2.6μMDopamine Receptor D4
EC50:2μM更多 
- 描述
- 参考文献
- [1] Farrell MS, McCorvy JD, et ak. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 2016 Mar 10;11(3):e0150602.
- [2] Wang X, Cheang WS, et al. Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms. Br J Pharmacol. 2015 Dec;172(23):5609-18.
- [3] Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 2016 Mar 10;11(3):e0150602. doi: 10.1371/journal.pone.0150602. PMID: 26963248; PMCID: PMC4786259.
- [4] Zhang C, Deng J, Liu D, Tuo X, Xiao L, Lai B, Yao Q, Liu J, Yang H, Wang N. Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. Br J Pharmacol. 2018 Nov;175(22):4218-4228. doi: 10.1111/bph.14482. Epub 2018 Oct 11. PMID: 30129056; PMCID: PMC6193881.
- [5] Zhang L, Gao J, Tang P, Chong L, Liu Y, Liu P, Zhang X, Chen L, Hou C. Nuciferine inhibits LPS-induced inflammatory response in BV2 cells by activating PPAR-γ. Int Immunopharmacol. 2018 Oct;63:9-13. doi: 10.1016/j.intimp.2018.07.015. Epub 2018 Jul 26. PMID: 30056259.
- [6] Wang MX, Zhao XJ, Chen TY, Liu YL, Jiao RQ, Zhang JH, Ma CH, Liu JH, Pan Y, Kong LD. Nuciferine Alleviates Renal Injury by Inhibiting Inflammatory Responses in Fructose-Fed Rats. J Agric Food Chem. 2016 Oct 26;64(42):7899-7910. doi: 10.1021/acs.jafc.6b03031. Epub 2016 Oct 18. PMID: 27718563.
- [7] Chen X, Zheng X, Zhang M, Yin H, Jiang K, Wu H, Dai A, Yang S. Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway. Inflamm Res. 2018 Dec;67(11-12):903-911. doi: 10.1007/s00011-018-1183-2. Epub 2018 Aug 25. PMID: 30145653.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 475-83-2 | 储存条件 |
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| 分子式 | C19H21NO2 | 运输 | 蓝冰 | |||||||
| 分子量 | 295.38 | 别名 | Sanjoinine E;(-)-Nuciferine;VLT 049|;VLT 049;荷叶碱 | |||||||
| 溶解度 |
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动物实验配方 |
